但令Leonard和Sheldon失望的是，美女对两人都没有意思，反而对花花公子Howard Wolowitz(Simon Helberg, "Studio 60 on the Sunset Strip")产生了好感。Howard绝对是那种可以俘获女人芳心的帅男，他甚至称自己是加州理工学院的"卡萨诺瓦"（1725-1798，意大利冒险家，以所写的包括他的许多风流韵事的《自传》而著称，后来该词被引申为"风流浪子，好色之徒")。喜欢有事没事围着别人转悠，大谈特谈相对论的 Rajesh Koothrappali (Kunal Nayyar, "NCIS")也引起了Penny的兴趣。
一个美女和四个科学怪才的故事就这样在笑声中悄然开始上演……
Created by writer/producers Chuck Lorre (of Two And A Half Men) and Bill Prady (of Gilmore Girls) comes The Big Bang Theory, a sitcom that shows what happens when hyperintelligent roommates/physicists Sheldon and Leonard meet Penny, a beautiful woman moving in next door--and realize they know next to nothing about life outside of the lab. Rounding out the crew are the smarmy Wolowitz, who thinks he's as sexy as he is brainy, and Koothrappali, who suffers from an inability to speak in the presence of a woman.
The show distinguishes itself by being unafraid to toss scientific references and technobabble into an otherwise standard sitcom, even employing a physicist to keep things accurate. In doing so, it allows Sheldon and Leonard to do for science what Frasier's Crane brothers did for fine dining, art, and opera.
Theme Song: "The History of Everything" by Barenaked Ladies
